Gary W Cline, PhD

Professor; Director, Analytical Core, Mouse Metabolic Phenotyping Center at Yale Univ. School of Medicine

Research Interests

Diabetes Mellitus; Endocrinology; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Lipid Metabolism

Research Organizations

Internal Medicine: Diabetes Research Center | Endocrinology: Fellowship Training

Faculty Research

Mouse Metabolic Phenotyping Center

Office of Cooperative Research

Research Summary

Diabetes mellitus has a profound impact on hepatic and peripheral glucose metabolic fluxes. My studies on the biochemical mechanisms responsible for the pathophysiology of diabetes mellitus primarily employ nuclear magnetic resonance spectroscopy, mass spectroscopy, and stable isotopic techniques. Using these techniques, the flux and fate of key intermediates of carbohydrate and lipid metabolism can be determined in vitro and in vivo. These techniques are developed in cell systems and small animal models and when appropriate applied to studies of human physiology. New areas of research are the application and adaptation of these techniques to the study of pancreatic beta-cell metabolism and glucose-stimulated insulin release.

Future Research
Recent dramatic improvement in the success rate of islet transplantation in humans has prompted interest for more widespread application of this methodology. My future research will explore the development of NMR based methods for non-invasive in vitro quality assessment of tissue destined for transplantation, and in vivo monitoring of islet transplants.

Selected Publications

  • Regulation of hepatic energy metabolism and gluconeogenesis by BAD.

    Regulation of hepatic energy metabolism and gluconeogenesis by BAD. Giménez-Cassina A, Garcia-Haro L, Choi CS, Osundiji MA, Lane EA, Huang H, Yildirim MA, Szlyk B, Fisher JK, Polak K, Patton E, Wiwczar J, Godes M, Lee DH, Robertson K, Kim S, Kulkarni A, Distefano A, Samuel V, Cline G, Kim YB, Shulman GI, Danial NN. Cell Metab. 2014 Feb 4;19(2):272-84. doi: 10.1016/j.cmet.2013.12.001.

  • Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

    Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis. Perry RJ, Zhang XM, Zhang D, Kumashiro N, Camporez JP, Cline GW, Rothman DL, Shulman GI. Nat Med. 2014 Jul;20(7):759-63. doi: 10.1038/nm.3579. Epub 2014 Jun 15.

Full List of PubMed Publications

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Contact Info

Gary W Cline, PhD
Mailing Address
Internal MedicinePO Box 208056
333 Cedar Street

New Haven, CT 06520-8056